Synthesis And Antifungal Activity Of Thiazole-Triazine | Original Article

ABSTRACT:

N-(arylmethylene)-4-(naphthalen-2-yl)thiazol-2-amine (3a-e) were synthesised  from 4-(naphthalen-2-yl)thiazol-2-amine (1) on reaction with different hetero aryl aldehydes (2a-e). The compounds (3a-e) then react with phenyl isocyanate and formed 3-aryl-6-(naphthalen-2-yl)-2-phenyl-2H-thiazolo[3,2-a][1,3,5]triazine-4(3H)-thione (4a-e).The structures of all the synthesised compounds were characterized by elemental and spectroscopies method. All the schiff bases (3a-e) and thiazole-triazinederivatives (4a-e) examined for their antifungal activity,which show that all the compounds have good antifungal activity.