Preparation and Antimicrobial Studies of Pyrazolo-Thiazole Fused Heterocyclic Compounds | Original Article

ABSTRACT:

ABSTRACT

2-[5-(4-Ary)furan-2-y]-3-(4H-1,2,4-triazol-4-yl)thiazolidin-4-one (Ia-e)  compounds [1] reacted with  furfural in the presence of sodium hydroxide affords, 5-[(furan-2-yl)methylen]-2-[5-(4-alkylphenyl)furan-2-y]-3-(4H-1,2,4-triazol-4-yl)thiazolidin-4-one (IIIa-e). These (IIIa-e) compounds reacted with Isoniazide yield [3-(furan-2-yl)-5-[5-(4-alkylphenyl)furan-2-yl]-6-(4H-1,2,4-triazol-4-yl)3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazol-2-yl](pyridin-4-yl) methanone (IVa-e). The molecular structures of all these novel heterocyclic derivatives  were confirmed  by elemental content and FTIR-NMR spectral features. The antimicrobial activity of all these derivatives were monitored.