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Nutrigenomic Effect of Micronutrient Vitamin c in The Management of Cancer | Original Article

Ram Haribhau Tekale in Anusandhan (RNTUJ-AN) | Multidisciplinary Academic Research




Nutrigenomic is science, study the relationship between human genome, human nutrition and health. Nutritional genomics is the relation between food and inherited genes. Nutritional research typically focuses on preventive measures trying to identify what nutrients or food will rise / lower risk of disease and damage to human body. Studies show that micronutrient (vitamins and minerals) has ability to change genetic expression by acting on gene. Micronutrient like vitamin A, vitamin C, vitamin D and mineral like selenium has ability to generate dietary signal. This dietary signal has role in maintain health and produce disease. With the help of this micronutrient we can prevent or control diet related disease like hypertension, diabetes mellitus and cancer. Cancer is most fatal disease and leading cause of death worldwide. Cancer is mutation of gene that cause uncontrolled cell growth. Micronutrient has ability to act on gene and change genetic expression. That helps change gene expression in mutant cancer cell and cause cell death. Among all the micronutrients Vitamin c has effective role in much type of cancer like colon, breast, tongue and laryngeal cancer. It causes death of cancerous cell through apoptosis, necrosis and necroptosis by acting on gene. It activate caspase independent pathway, PKC (protein kinase c) and increase intracellular ROS (reactive oxygen species) which cause death of cancerous cell. Vitamin c has cytotoxic and cytostatic effect on cancerous cell. Too high dose of vitamin c may cause cytotoxic effect on normal cell. Is has carcinostatic effect and also has ability to cell cycle arrest. Cell cycle arrest prevent cell division. That help to prevention of cancer growth. Vitamin c may has preventive role in different type of cancer. It may help to prevention of cancer growth.